HsCRP in patients with acute exacerbation of chronic obstructive pulmonary disease

ABSTRACT

Chronic obstructive pulmonary disease [COPD] is currently the fourth leading cause of death in the United States. As there is systemic as well as local inflammation in COPD patients and evaluating the stage of the disease is not possible by spirometery alone, we evaluated High-Sensitivity C-reactive Protein [HS-CRP] in a group of COPD patients as an available and cost effective auxiliary marker in determining COPD stages. In a cross-sectional study in 160 COPD patients who were admitted for exacerbations in Razi Hospital in Rasht, Data on patients' demographic characteristics, pulmonary function test [PFT] and laboratory results consist of arterial blood gases and HSCRP levels were analyzed. A significant positive correlation was seen between serum HSCRP level and stages of the disease [as GOLD criteria]. There was a significant relationship between HSCRP level and patients' sex, BMI, and smoking history in a way that men and smokers showed higher and patients with normal BMI showed lower HSCRP levels. The patients with higher PCO2 also showed a higher level of serum HSCRP. This survey supports the role of HSCRP as a simple auxiliary marker in staging and determining the prognosis of COPD for early management