Bilateral orchiectomy with or without flutamide for advanced carcinoma prostate

ABSTRACT

To assess the effects of flutamide in patients suffering from advanced carcinoma of the prostate who underwent bilateral orchiectomy. Institute of Kidney Diseases, Hayatabad Medical Complex, Peshawar, from March 2008 to July 2009. A total of 100 patients having advanced carcinoma prostate who had undergone bilateral orchiectomy were divided into two groups .Group A consisted of 50 patients who were treated with flutamide while group B having 50 patients received placebo. Relief of bone pain was more in group A than B. No significant difference was seen in the occurrence of adverse effects like nausea, vomiting, hot flashes and anemia between the groups. Eight patients in each group were lost to follow up. The benefit of combined androgen blockade was better in relief of bone pain