New syntheses of pyrazolo [3,4-d] pyrimidine, Pyrazolo- [3,4-d] Pyridazine, Benzpyrrole and Pyrazole derivatives

ABSTRACT

Phenacyl malononitriles 2 reacted with hydrazines, acetichydrochloric acid and with diazotised primary aromatic amines to afford phenacylpyrazole, enaminofuran and enaminopyrazole derivatives respectively. The synthesized derivatives were the key materials for the synthesis of benzopyrrole, pyrazolopyrimidine and pyrazolopyridazine derivatives. The structures of the newly synthesized heterocycles were established on the basis of elemental analyses and spectral data besides synthesis via other routes