Anti-ulcer activity of the leaves of toddalia asiatica linn

ABSTRACT

The anti-ulcer activity of the leaves of Toddalia asiatica [Family Rutaceae] was studied on albino rats. The anti-ulcer activity of the petroleum ether extract, chloroform extract, ethanol and aqueous extract was evaluated by using pyloric ligation and aspirin-induced ulceration models. In both the models, Ranitidine was used as standard drug for comparison. All the test samples revealed significant anti-ulcer activity except petroleum ether extract in aspirin plus pylorus ligated ulceration model. The order of decreasing ulcer score was found to be aqueous extract < ethanolic extract < chloroform extract < petroleum ether extract. The results indicate that the leaves of Toddalia asiatica are endowed with potential anti-ulcer activity