[Assessment of aqueous extract of seed of cuminum cyminum L. on neurogenic and inflammatory pain in mice]

ABSTRACT

The side effects of antinoceception chemical drugs, induced notice to many medical plants [Cuminum cyminum L.] which have modulatory effect in pain. The present work investigated the effects of aqueous extract of Cuminum cyminum [CC] on neurogenic and inflamatory pain in Formalin test in mice. 50 male albino mice [20-30 gr] were used. CC [200, 500 and 1000 mg/kg] and saline were injected 30 min before formaline test. Indices of signs were licking and foot elavation for assessment of acute pain [5 min] and chronic pain [15-40 min] after injection of formaline 5% [25 micro l] in paw. Results indicated that CC has analgesic effect in all doses [p<0.01] but 200 mg/kg in acute phase and 1000 mg/kg in chronic phase was more effective. Finding showed that aqueous extract of CC can modulate acute and chronic pain. Further research is required to determine the mechanism [s] by which CC has an inhibitory effect on pain sensation