Diffuse skin hyperpigmentation in CD30+ lymphoproliferation
Annals of Saudi Medicine. 2012; 32 (3): 318-320
em Inglês
| IMEMR
| ID: emr-128516
ABSTRACT
CD30+ T-cell lymphoproliferative disorders [LD] comprise two main groups of diseases CD30+ LD of the skin and systemic anaplastic large cell lymphoma [ALCL]. The main feature of these disorders is the expression of CD30. We present a patient with an unusual clinical presentation of CD30+ lymphoproliferative disease in a 54-year old Caucasian male who presented with generalized lymphadenopathy and pronounced skin hyperpigmentation. In the lymph nodes and skin, CD30+ lymphoproliferation [ALCL] was diagnosed. The Prussian blue staining identified that the pigment responsible for the skin color was hemosiderin. Chemotherapy was started but the patient's condition progressively worsened and he died a week after the first cycle. The complete color transformation of the entire skin due to hemosiderin accumulation is, to the best of our knowledge, the first reported observation in a CD30+ lymphoproliferation/ALCL patient. We speculate that hemosiderin-loaded macrophages resulted from the paraneoplastic process by some still unknown mechanism
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Pele
/
Imuno-Histoquímica
/
Hiperpigmentação
/
Antígeno Ki-1
/
Hemossiderina
/
Doenças Linfáticas
/
Transtornos Linfoproliferativos
Tipo de estudo:
Relato de Casos
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Ann. Saudi Med.
Ano de publicação:
2012
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