pattern of dyslipoproteinemia in non- dialyzed chronic renal failure patients

ABSTRACT

Dyslipidemia is a common finding among patients with chronic renal failure [CRF] Lipid abnormality in CRF is a risk factor for atherosclerosis which is one of the leading causes of death in uremia. In biochemical lipid studies, the absolute and relative Concentrations of individual fractions of circulating triglyceride and cholesterol in different lipoprotein classes are more significant than their serum total levels. However, such studies are obviously rare. The aim of this study was to determine plasma triglyceride and cholesterol contents of VLDL. LDL and HDL classes in patients with chronic renal failure [not yet undergoine dialysis] due to chronic renal disease and to compare the data with their similar results in matched normal subjects. Twenty five male patients with chronic renal disease and CRF were recruited from Mansoura University Hospitals. Also twelve healthy male subjects matched for age and body weight were simultaneously investigated as a normal control After 12 hr overnight fast, blood samples were drawn into EDTA tubes and plasma were separated. Different plasma lipoproteins were layered by high performance density gradient ultracentrifugation. This was followed by measurement of triglyceride and cholesterol fractions in the different lipoprotein layers by the respective enzymatic-colon metric method. There were significant increases in plasma VLDL-TG, LDL-TG and HDL-TG values in CRF above the corresponding normal values. This induced significantly higher than normal circulating TG concentrations. At the same time, there were significantly lower LDL-C and HDL-C concentrations and significantly higher VLDL-C mean value in uremic patients than the corresponding value in the control. The sum of the different lipoproteins cholesterol concentrations gave insignificant change in total serum cholesterol concentration in CRF patients in comparison to normal control. All lipoproteins participate in carrying the excess triglyceride. Cholesterol bounds to lipoproteins was subnormal as regard LDL and HDL but higher than normal with VLDL. HypertrigIyceridemia enhances atherosclerosis of cerebral and/or coronary arteries in CRF