Inflammatory biomarkers in patients with asymptomatic primary hyperparathyroidism

ABSTRACT

To assess highly sensitive C-reactive protein [hs-CRP] and interleukin-6 [IL-6] as inflammatory biomarkers in patients with asymptomatic primary hyperparathyroidism [PHPT]. A total of 26 patients with asymptomatic PHPT and 22 age- and sex-matched individuals as a control group were recruited for the study. Corrected serum calcium, phosphorus, alkaline phosphatase, serum 25-hydroxyvitamin D, intact parathyroid hormone [PTH], hs-CRP and IL-6 were measured for all subjects. Serum hs-CRP and IL-6 were significantly higher in asymptomatic PHPT patients than in the control group [hs-CRP 4.15 +/- 0.54 vs. 2.24 +/- 0.11 mg/l; IL-6 4.50 +/- 0.80 vs. 2.56 +/- 0.29 pg/ml; p < 0.001]. Moreover, in asymptomatic PHPT patients, serum PTH was significantly correlated with hs-CRP and IL-6 [r = 0.820, p < 0.001 and r = 0.787, p < 0.001, respectively]. Inflammatory biomarkers were higher in patients with asymptomatic PHPT than in controls. Moreover, serum PTH was significantly correlated with inflammatory biomarkers which may suggest a subclinical inflammatory response in this group of patients