Effect of dexamethasone on striatal neurotransmissions in the rats subjected to Parkinson's disease animal model
Iranian Journal of Basic Medical Sciences. 2011; 14 (2): 107-115
em Inglês
| IMEMR
| ID: emr-129645
ABSTRACT
The aim of this study was to evaluate the effects of dexamethasone on striatal dopaminergic, glutamatergic and gamma amino butyric acid [GABA] ergic neurotransmission in normal and parkinsonian rats. Dexamethasone [0.15, 0.30, 0.60 and 0.8 mg/kg] was administered to normal or parkinsonian rats [i.p.] followed by the analysis of the striatal neurotransmitters concentrations. Additionally, the effect of dexamethasone on the damaged Substantian nigra pars compata [SNc] neurons has been investigated. Dexamethasone resulted in decreased level of striatum glutamatergic-GABAergic and enhanced dopaminergic neurotransmission in normal and parkinsonian rats. In addition, acute treatment with dexamethasone did not improve the lesion at all. These findings suggest the new therapeutic mechanism of action for dexamethasone in Parkinson's disease animal model
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Doença de Parkinson
/
Dexametasona
/
Dopamina
/
Ratos Wistar
/
Ácido Glutâmico
/
Modelos Animais
/
Ácido gama-Aminobutírico
Limite:
Animais
Idioma:
Inglês
Revista:
Iran. J. Basic Med. Sci.
Ano de publicação:
2011
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