Effect of aqueous-ethanolic extract from Rosa damascene on guinea pig isolated heart
Iranian Journal of Basic Medical Sciences. 2011; 14 (2): 116-121
em Inglês
| IMEMR
| ID: emr-129646
ABSTRACT
In the present study, the effects of aqueous-ethanolic extract from Rosa damascene on heart rate and contractility were examined. Isolated guinea-pig hearts were perfused through aorta in a Langendorff mode. Heart rate [HR] and contractility were determined in the presence of four concentrations of the extract [0.1, 0.2, 0.4 and 1.0 mg%] and isoprenaline [1, 10, 100 nM and 1 micro M] in comparison with baseline values in the presence and absence of propranolol [n= 10 for each group]. Both isoprenaline and the extract caused increase in heart rate and contractility [P< 0.05 to P<0.001]. The percent increased in HR due to the final concentration of isoprenaline in the absence of propranolol was significantly greater than that of the extract [P< 0.01]. Propranolol caused significant reduction in both HR and contractility [P<0.05 for both] but this effect was significantly reversed by isoprenaline and the extract [P<0.05 to P<0.001]. The percent increased in heart contractility due to the final concentration of the extract in the absence and presence of propranolol was significantly greater than that of isoprenaline [P< 0.05 for both cases]. There was significant correlation between both HR and heart contractility with concentration of isoprenaline and the extract [P<0.05 to P<0.001]. In conclusion this study showed a relatively potent inotropic and chornotropic effect for Rosa damascene on isolated guinea-pig heart
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Extratos Vegetais
/
Receptores Adrenérgicos beta
/
Etanol
/
Cobaias
/
Coração
/
Fitoterapia
Limite:
Animais
Idioma:
Inglês
Revista:
Iran. J. Basic Med. Sci.
Ano de publicação:
2011
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