Do the Cyclooxygenase-2 inhibitors accentuate the cognitive activities?

ABSTRACT

Cognition is a process of knowing. When it is impaired, reviving is needed. Studies to bustle off the psychomotor activities using non steroidal anti-inflammatory drugs revealed variable results. The aim of this study is to evaluate the effects of single oral dose of celecoxib and meloxicam on cognitive activity in healthy, young volunteers. Fourteen healthy young volunteers were participated, allocated into two groups. After a7-day washed-out period, each volunteer was randomly given a single oral dose of either celecoxib or meloxicam or placebo. Psychomotor tests were performed to record participants' sensory and motor reactions. placebo-administered subjects had non-significant changes in both choice reaction time and critical flicker fusion. Celecoxib-administered participants had a significantly reduced recognition reaction time without a significant effect on motor reaction time. While meloxicam-administered participants had a significant reduction in motor reaction time without a significant effect on recognition reaction time. All drug-given participants had a non-significant change in choice reaction time when compared with corresponding baseline and placebo values. Cox-2 inhibitors have no place in improving the cognition