[ effect of concomitant administration of furosemide and salbutamol on spirometry parameters in persistent asthma]

ABSTRACT

Considering the effectiveness of nebulized furosemide in asthma crisis that were non-responsive to the inhalational beta-agonists, this study aimed to examine the effect of concomitant administration of furosemide [10 mg] and nebulized salbutamol [2.5 mg] on spirometry parameters in persistent asthma. In this clinical trial, 53 patients [age, 18-75 years] with a 6-months history of persistent asthma were randomly allocated to two groups, the salbutamol [n=27] and salbutamol + furosemide [n=26] groups. Participants in each group were classified into the mild, moderate and severe persistent asthma on the basis of FEV1. Participants were administered salbutamol or salbutamol + furosemide, and then the spirometry parameters were recorded 15 minutes after the completion of nebulization treatment. Before and after the treatment, mean and standard deviation of the spirometry parameters and their changes were calculated. Results showed no significant difference regarding the mean percentage change for FEV1 in the salbutamol [27.5%] and salbutamol + furosemide groups [25.83%] after the treatment [P=0.72]. Moreover, no significant difference was seen between the two groups regarding the mean percentage changes in other parameters after the treatment [FVC, FEV1, PEF, MMEF, FEV1/FVC, P>0.25]. Concomitant administration of furosemide and salbutamol has no advantage over salbutamol in normalizing the spirometry parameters of persistent asthma