Expression and prognostic significance of Bcl-2 and Bax in the progression and clinical outcome of transitional bladder cell carcinoma
Cell Journal [Yakhteh]. 2014; 15 (4): 356-363
em Inglês
| IMEMR
| ID: emr-130710
ABSTRACT
To evaluate the mRNA expression ratio of Bcl-2/Bax both in normal and tumoral bladder tissues of patients with transitional cell carcinoma [TCC] of bladder and investigate potential correlation between this expression ratio and clinical outcome. In this experimental study, we used real time-PCR to investigate the expression of Bcl-2 and Bax both in normal and tumoral bladder tissues. The Bcl-2/Bax expression ratio was determined in tumoral bladder tissues of patients with transitional cell carcinoma of the bladder [n=40] and correlation between expression ratios and the emergence of early relapses in a follow-up of 14-30 months was examined. Relapse-free time in 14/31 patients [45.16%] with Bcl-2/Bax>1 was shorter than 9 months [range of 2-9 months] with 5.7 months average median while 17/31 patients [54.84%] with Bcl-2/Bax<1 are currently relapse-free [14-30 months]. Bcl-2 and Bax expression levels were not solely correlated with clinical outcome and progression of carcinogenesis. The mRNA expression ratio of Bcl-2/Bax in tumoral bladder tissues may serve as a significant prognostic indicator in predicting the clinical outcome in low grade non-invasive bladder cancer
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
RNA Mensageiro
/
Carcinoma de Células de Transição
/
Genes bcl-2
/
Proteína X Associada a bcl-2
/
Reação em Cadeia da Polimerase em Tempo Real
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Cell J. [Yakhteh]
Ano de publicação:
2014
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