Synthesis and evaluation of some new substituted 2-Aryl-3-[4'-[1"-[3"'-chlorophenyl]- phthalazine]]-4-thiazolidione as potential antifungal and insecticide
Hamdard Medicus. 2010; 53 (4): 119-123
em Inglês
| IMEMR
| ID: emr-131134
ABSTRACT
2-[3-chlorophenyl]-benzamide was condensed with hydrazine hydrochloride in presence of 10% NaOH to yield 1-[3-chlorophenyl]-4-amino pththalazine [I]. Seven new Schiff bases [II a-g] have been synthesized by the interaction of I with different aromatic aldehyde in dioxane. In final step II was condensed with thioglycolic acid in the presence of acetic acid to yield substituted-2-aryl-3-[4'[1"-3"'-chlorophenyl] phthalazine]]-4-thiazolidione. The synthesized compounds have been characterized by elemental analysis, IR, PMR and Mass spectral analysis and screened for antifungal and insecticidal activity
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Tiazolidinas
/
Inseticidas
/
Antifúngicos
Idioma:
Inglês
Revista:
Hamdard Med.
Ano de publicação:
2010
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