[Comparative study of therapeutic effects of two medicinal procedures of fluoxetine in premature ejaculation]

ABSTRACT

Comparative study of therapeutic effects of two medicinal procedures of fluoxetine 3 hours before coitus and each 12 hours, and declining symptoms of SSRI drugs in patients through decreasing dosage and therapeutic procedure in patients refer to 501 hospital and private clinic. The procedure of this study is based on non stochastic clinical test without quasi drug group and a comparison from therapeutic effect and symptoms of two medicinal procedures of fluoxetine 4 hours before coitus and each 12 hours in premature ejaculation treatment in 88 patients refer to 501 hospital and private clinic. Patient were divided into two groups in peradventure manner. In first group, it is prescribed 20mg of fluoxetine daily 4 hours before coitus in 39 patients and 2nd groups group, it is prescribed 20mg of fluoxetine each 12 hours before coitus in 49 patients. Finally it was analyzed data in SPSS software. The average of ejaculation duration in fluoxetine group 4 hours after coitus before treatment was 139.97 Sec. that after 4 weeks of hospitalization reached to 225.25 and p.v 0.0000 and after 8 weeks to 261.153 Sec. and p.v.0.0000 and in compare with ejaculation duration between 4th and 8th weeks it gained p.v 0.003. The average of ejaculation duration in fluoxetine group 12 hours after coitus before treatment was 107.04 Sec. that after 4 weeks of hospitalization reached to 294.08 and p.v 0.0000 and after 8 weeks to 324.08 Sec. and p.v0.0000 and in compare with ejaculation duration between 4th and 8th weeks it gained p.v0.029. In comparing ejaculation duration between 2 groups' fluoxetine 4 hours before coitus [t=225.25] and each 12 hours [t=294.08] in 4th week after treatment it gained p.v0.03. In comparing ejaculation duration between 2 groups' fluoxetine 4 hours before coitus [t=261.153] and each 12 hours [1=324.08] in 8th week after treatment it gained p.v0.000. Symptom measure in fluoxetine group 4 hours before coitus 12.8% and symptom measure in fluoxetine group 12 hours before coitus 44.9% and p.v0.001. In this study, both drug method improved ejaculation duration but in 2nd group it was considerably higher than the 1st one. Also from symptom point of view, symptoms in fluoxetine group each 12 hours was considerably higher than group with 4 hours before coitus