Fatal hepatitis B reactivation treated with entecavir in an isolated anti-HBs positive lymphoma patient: a case report and literature review
Saudi Journal of Gastroenterology [The]. 2012; 18 (4): 277-281
em Inglês
| IMEMR
| ID: emr-132550
ABSTRACT
Hepatitis B virus [HBV] reactivation is a well-recognized complication that occurs in lymphoma patients who undergo chemotherapy. Only very few cases of HBV reactivation in patients with isolated antibody against hepatitis B surface antigen [anti-HBs] have been reported. We present a case of a 78-year-old woman diagnosed with diffuse large B cell non-Hodgkin's lymphoma who only displayed a positive anti-HBs, as the single possible marker of occult HBV infection, before starting therapy. She was treated with several chemotherapeutic regimens [including rituximab] for disease relapses during 3 years. Forty days after the last cycle of chemotherapy, she presented with jaundice, markedly elevated serum aminotransferase levels, and coagulopathy. HBV serology showed positivity for HBsAg, anti-HBc and anti-HBs. HBV DNA was positive. Antiviral treatment with entecavir was promptly initiated, but the patient died from liver failure. A review of the literature of HBV reactivation in patients with detectable anti-HBs levels is discussed
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Linfoma não Hodgkin
/
Literatura de Revisão como Assunto
/
Vírus da Hepatite B
/
Anticorpos Monoclonais Murinos
/
Guanina
/
Antígenos de Superfície da Hepatite B
Tipo de estudo:
Relato de Casos
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Saudi J. Gastroenterol.
Ano de publicação:
2012
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