Protective effects of N-Acetyl-L-cystein on 3,4-Methylene Dioxymethamphetamie-induced Neurotoxicity in Cerebellum of male rats
Basic and Clinical Neuroscience. 2011; 3 (1): 44-47
em Inglês
| IMEMR
| ID: emr-132587
ABSTRACT
3-4, methylenedioxymethamphetamine [MDMA] causes apoptosis in nervous system and several studies suggest that oxidative stress contributes to MDMA-induced neurotoxicity. The aim of this study is to examine the effects of N-acetyl-L-Cystein [NAC] as an antioxidant on MDMA-induced apoptosis. 21 Sprague dawley male rats [200-250mg] were treated with MDMA [2x0,5mg/kg] or MDMA plus NAC [100mg/kg IP for 7 day]. After last administration of MDMA, rats were killed, cerebellum was removed and Bax and Bcl-2 expression was assessed by western blotting method. The results of this study showed that MDMA causes up-regulation of Bax and down-regulation of Bcl-2 and NAC administration attenuated MDMA-induced apoptosis. The present study suggests that NAC treatment may improve MDMA-induced neurotoxicity.
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Cerebelo
/
Ratos Sprague-Dawley
/
Apoptose
/
Estresse Oxidativo
/
Fármacos Neuroprotetores
/
N-Metil-3,4-Metilenodioxianfetamina
/
Síndromes Neurotóxicas
/
Antioxidantes
Limite:
Animais
Idioma:
Inglês
Revista:
Basic Clin. Neurosci.
Ano de publicação:
2011
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