[HLA-DR /DQ antigens associations in recurrent abortions for women from Syrian population]

ABSTRACT

Many available references indicate to a role for HLA-antigens in recurrent abortions, during their function in self and non-self recognition. The embryo, being hemi-allograft, make it rational to search for some HLA-antigens more frequent in women suffering from recurrent abortions in Syrian population, especially HLA-II antigens HLA-II antigens. Searching also for combined haplotypes between these antigens. We did not found any like study in Syrian population. The Antigens types of HLA-DR and HLA-DQ of [14] fertile multifarious Syrian couples[controls] were defined by micro lymphocytotoxicity test[Terazaki method]. In the same time, antigen types of DR and DQ of [36] Healthy Syrian couples suffering from recurrent abortions were defined by the same technique. The results indicate different antigen pattern distribution between control and diseased groups. The frequencies in control group for DR types were as the following DR429%, DR1118%, DR1514%, DR1 7%, DR7 7%, DR8 7%, DR16 7%, DR3 4%, DR12 4%, DR14 4%. And in the diseased group were DR418%, DR1118%, DR7 11%, DR1 10%, DR14 7%, DR17 7%, DR13 6%, DR15 6%, DR8 6%, DR3 4%, DR12 3%, DR9 1%, DR10 1%, DR16 1%, DR18 1%. The frequencies in control group for DQ types were DQ3 29%, DQ4 25%, DQ5 21% DQ2 14%, DQ6 11%. And in the diseased group were DQ3 28%, DQ5 25%, DQ2 18%, DQ4 15%, DQ6 14%. The obvious frequency changes for DR types were DR1, DR7, DR4, D15, DR13, DR17, DR14 and for DQ types were DQ2, DQ4, DQ5, DQ6. The differences of DR -DQ types distributions in the studied group of control [women and men] are similar to those in other studies in the Syrian population. This study suggest that having antigen types of DR-DQ in frequencies different from control observed in the whole population make them at risk to inconvenient immunological response to accept pregnancy the result of which is abortion.