[Two sister, two paget, two metabolic disease]

ABSTRACT

Paget bone disease is a metabolic disease with unknown pathogenesis. We report the observation of two sisters with Paget disease, having a dyslipidemia past and one of them had diabetes mellitus. They both presented headache, vertigo and skull deformation. Paget bone disease diagnosis was held on phosphatase alkaline increase and radiologic investigations. Across these observations we remind clinical signs and diagnosis management of Paget disease. We discuss one etiology of this pathology, that may be genetic. Association of Paget disease and diabetes mellitus has been reported in one case