[Natural history of untreated hepatocellular carcinoma in patients with post virus B cirrhosis about 34 cases]

ABSTRACT

The aim of the present study was to evaluate the natural history of untreated hepatocellular carcinoma [CHC] developing in patients with post viral-B cirrhosis. A retrospective analysis was performed in 34 cases of CRC, admitted at Gastroenterology Department in Sfax. Survival and prognostic factors were evaluated. There were 28 men and 6 women [sex-ratio=4, 6] with a mean age of 59, 5 years. The mean time from the diagnosis of cirrhosis to CHC was 8, 9 months. The circumstances of the diagnostic of the CHC were as follows The follow up of a known cirrhosis in 8 cases [23, 5%]. the decompensation in 10 cases [29, 5] and the clinical manifestations dominated by abdominal pain in 14 cases [47]. Cirrhosis was evaluated as Child-Pugh A, B and C in respectively in 26, 5%, 47, 1%and 26, 4%of cases. The tumor was solitary in fifty per cent of cases. The overall median survival was 51 days [IC 95=42, 7-59, 31 from the time of diagnosis of CRC. The only prognostic factor was the serum bilirubin with a median survival of 34 days when it was superior to 34micro mol [IC 95=25, 1-48,8] [p<0.004]