Anti inflammatory and analgesic alkaloid from Sida cordifolia Linn
Pakistan Journal of Pharmaceutical Sciences. 2007; 20 (3): 185-188
em Inglês
| IMEMR
| ID: emr-134957
ABSTRACT
The analgesic and anti-inflammatory activities of a new alkaloid, 1,2,3,9-tetrahydro-pyrrolo [2,1-b] quinazolin - 3-ylamine [compound 1] isolated from Sida cordifolia Linn. were investigated in animal models. In the acetic acid induced writhing model, the compound 1 showed 25.4 [p<0.05] and 52.43% [p<0.01] inhibition of writhing response at doses of 25 and 50 mg/kg body weight respectively. The alkaloid also produced significant increase in the tail flick latency in radiant heat tail-flick method. In Carrageenan induced rat paw edema the compound 1 produced 16.93 and 24.43% inhibition of paw edema at the doses of 25 and 50 mg/kg body weight respectively at the third hour of study
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Ratos Long-Evans
/
Alcaloides
/
Analgésicos
/
Camundongos
/
Anti-Inflamatórios
Limite:
Animais
Idioma:
Inglês
Revista:
Pak. J. Pharm. Sci.
Ano de publicação:
2007
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