Neurochemical and behavioral effects of M-CPP in a rat model of tardive dyskinesia
Pakistan Journal of Pharmaceutical Sciences. 2007; 20 (3): 188-195
em Inglês
| IMEMR
| ID: emr-134958
ABSTRACT
Present study was designed to monitor the responsiveness of 5HT [5-Hydroxytryptamine] -2C receptors following the long-term administration of haloperidol in rats. Effects of m-CPP [meta-Chlorophenyl piperazine] were monitored 48h after withdrawal from repeated [twice a day for 5 week] administration of haloperidol [at the dose of 1mg/kg]. Vacuous chewing movements [VCMs] were monitored on weekly basis. Two days after withdrawal, animals were injected with saline [1ml/kg of body weight] or m-CPP [3mr/kg of body weight]. Activities in open field and light dark activity box were monitored 15 and 30 min post injection respectively. Animals were then decapitated [4h post injection] to collect dorsal striatum [DS] samples for the neurochemical analysis by HPLC-EC [High performance Liquid Chromatography with Electrochemical detection] method. Results from the present study showed significant hypolocomotive effect of m-CPP [p<0.05] in both repeated haloperidol as well as repeated saline injected rats. Neurochemical analysis of DS by HPLC-EC method showed that administration of m-CPP significantly [p<0.05] decreased 5-HIAA [5-Hydroxyindol acetic acid] in repeated haloperidol injected rats. In conclusion, present study provides evidence that 5HT-2C receptors become hypersensitive in a rat model of Tardive Dyskinesia [TD]. These findings have potential implication in the treatment of TD and attenuation of EPS induced by typical neuroleptics
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Piperazinas
/
Ratos
/
Comportamento
/
Receptores de Serotonina
/
Discinesia Induzida por Medicamentos
/
Tratos Extrapiramidais
/
Neuroquímica
Limite:
Animais
Idioma:
Inglês
Revista:
Pak. J. Pharm. Sci.
Ano de publicação:
2007
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