Inhibition of posterior capsule opacification after extracapsular cataract extraction by 5-fluorouracil in rabbits

ABSTRACT

This work was designed to study the effect of 5-fluorouracil on prevention of posterior capsule opacification after extra-capsular cataract extraction as well as it's effect. On the corneal endothelium and uveal tissue. The study was done on 30 eyes of 15 pigmented rabbits with the left eye as a control, while the right eyes were irrigated with three different concentrations of 5-fluorouracil dividing them into 3 groups. The first group was irrigated with 50 mg/15-fluorouracil, the second group was irrigated with 40 mg/15-fluorouracil and the third group was irrigated with 30 mg/15-fluorouracil [5 -FU]. Postoperative follow up was done for 2 month and the study revealed a statistically significant reduction of the posterior opacification. Also the ocular complications were least with the lowest concentration of 5-fluorouracil