curative and prophylactic propertics of sotalol and propranolol on adrenaline induced arrhysthmia

ABSTRACT

Sotalol is a non selective beta adrenoceptor blocking agent that differs from propranolol in having no membrane stabilising properties. In the present study the antiarrysthmic, effect of sotalol was shown when injected immediately after, or 2 minutes before adrenaline injection in anaesthetised dogs. 2mg/ Kg b.w. sotalol prevented as well as cured arrhythmic effect of even large dose of adrenaline while 0.2mg/ Kg b.w. propranolol was needed to produce the same effect. Sotalol was also evaluated clinically as regards its usefulness against the cardiac arrhythmia that may arise in patients after infiltration of adrenaline in the presence of halothane anaesthesia