Synthesis of certain 1,5-diazepine derivatives of expected CNS depressant activity

ABSTRACT

A series of compounds of fused 1,5-diazepine structure, 3-substituted by an arylhydrazono group 7-methyl-3-arylhydrazono-1,5-benzodiazepin 2-ones [7-12] and 3-arylhydrazono-pyrido [2,3-b] 1,5-diazepin-2-ones [13-18] have been synthesized, with special incorporation of fluoro, trifluoromethyl and methylmercapto functions at the arylhydrazono moiety. The pharmacological screening of these new compounds is under investigation