L'hormonotherapie en matiere de cancer du sein

ABSTRACT

Breast cancers hormonotherapy occupies a preponderant place in the adjuvant treatment of breast cancer. It date from the end of the last century cohen BEATSON proposed the ovariectomy in 1896. The hypophysectomy have been proposed in 1952, it gives a subjective amelioration going from 30 to 36%. Its indications became exceptional. The chirurgical suprarenalectomy have been used by HUGGINS and BERGENSTAL. The medical suprarenalectomy have obstained by corticoids and aminoglutethimide concerning the additive hormonotherapy, estrogens and androsgens aren't no more used. Progestatives are effective with large dose. As for antiestrogens, they are the most used actually; particularrly tomoxifin which the effectiveness and good tolerance tend to use it more in the treatment of advanced breast cancers. In the end dosages of [RE and RP] in middle of the swelling permited to rationalize and optimize the prescription