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Drug induced liver injury: a review article
Govaresh. 2011; 15 (4): 293-302
em Inglês, Persa | IMEMR | ID: emr-137309
ABSTRACT
The incidence of drug induced liver injury [DILI] is about 1/1000 to 1/10000 among patients who receive therapeutic drug doses. Drug induced hepatotoxicity is a major cause of acute and chronic liver disease. The severity of liver damage ranges from nonspecific changes in liver structure to acute liver failure, cirrhosis and liver cancer. Some common agents that can cause liver injury are acetaminophen, antibiotics, statins, INH and herbal drugs. Drug-induced hepatotoxicity can be categorized based on the pattern of liver enzyme alteration [hepatocellular, cholestatic or mixed pattern], the mechanism of hepatotoxicity [direct, immune mediated or idiosyncratic] and hjstologic findings on liver biopsy [steatosis or sinusoidal obstruction syndrome]. Treatment options for DILI include discontinuing the drug, conservative measurements and liver transplantation in the case of non-acetaminophen induced hepatotoxicity
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Índice: IMEMR (Mediterrâneo Oriental) Assunto principal: Falência Hepática Aguda / Falência Hepática / Doença Hepática Induzida por Substâncias e Drogas / Hepatopatias Limite: Humanos Idioma: Inglês / Persa Revista: Govaresh Ano de publicação: 2011

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Índice: IMEMR (Mediterrâneo Oriental) Assunto principal: Falência Hepática Aguda / Falência Hepática / Doença Hepática Induzida por Substâncias e Drogas / Hepatopatias Limite: Humanos Idioma: Inglês / Persa Revista: Govaresh Ano de publicação: 2011