comparative study of antioxidant vitamins and simvastatin in hypercholesterolimic rabbits

ABSTRACT

The anti-lipidemic effects of orally administered antioxidant vitamins [vitamin A, vitamin C and vitamin E] individually and in combination were studied in cholesterol-fed rabbits and compared to the group of hypercholesterolemic animals that were treated with simvastatin. All treatment groups exhibited a decrease in serum total cholesterol, low density lipoprotein-cholesterol [LDL-C] and triglycerides concentrations, whilst vitamin C, vitamin E, the combination and simvastatin showed a more profound decrease in the lipid profile than vitamin A at different time intervals. The order of increase in high density lipoprotein-cholesterol [HDL-C] levels remained in favour of simvastatin, as none of the antioxidant vitamins treated group could exhibit a profound increase in the HDL-C