Activation of complements pathways in patients with Bechcet's disease

ABSTRACT

Behcet's disease [BD] is amultisystemic inflammatory disorder, onset is belived to be triggered by many factors with a particular immunogenetic Factor. The aim of this study is elucidate the role of C3,C4 complement components With CH50 and HLA typing as immunogenetic factor in aetiopathogenesis of this disease. Seventy patients with Behcet's disease have been studied to assess the level of serum complement's components [C3,C4], complement total hemolytic activity [CH50], and HLA- typing using single radial immunodifusion [SRID], titration assay, and microlymphocytotoxicity methods respectively, compared with age, sex and ethic matched 30 patients control with recurred oral ulcer, 25 healthy relative, and 30 healthy volunteer. Significant elevation [P<0.01,0.05,0.0005] in C3, C4 and CH50 levels was clearly observed in patients with BD, especially those who show to be HLA-B51[5] positive in comparison to control groups. Increased level ofCH50 which is reflected the total activity of the classical and lytic pathways, elevation of C3 level is an index of the disease activities which support that alternative pathway play a role in the pathogenesis of BD in Iraqi patients especially in those with HAL - B51[5] positive