Specific IgE antibodies to sarcoptes scabiei in scapetic patients also recognize house dust mites antigens

ABSTRACT

Scabies is relatively a highly contagious inflammatory skin disease caused by infestation with a parasite Saivoptes s_cabici. The pathogenesis of scabies is mainly due to and starts after sensifl/ation of the host to the mite and its products which provokes an allergic response, responsible for a wide spectrum of clinical and histological manifestations. To determine whether specific IgE against scabies can show a cross reactivity with house dust mites allergens. The level of specific IgE. Against Sarcoptes scabiej_ var hominis, Dermatophagoides faiinae and Dermatophagoides pteronyssinus was measured in 30 scabietic patients by ELIZA method and [he results was compared using t test with that from the control group. There was a high statistical correlation [P<0.001] between the data of specific IgE against Sarcoptes scabiei var hominis, Dermatophagoides farinae and Dermatophagoides pteronyssinus in the patient group in comparison with that from the control group. Some antigens from Sarcoptes scabiei body and its fecal pellets cross react with house dust mites body and feces, since they are related phylogenetically. So specific IgE against scabies can cross react with house dust mites, Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are important allergens responsible for extrinsic asthma. This cross reactivity may explain the association of severe form of scabies infestation with atopic diseases and the persistence of symptoms in some cases even after proper treatment of the disease