lnterleukin-6 level in serum of Iraqi patients on maintenance hemodiaiysis therapy

ABSTRACT

Chronic renal failure [CRF] is characterized by progressive destruction of renal mass with irreversible sclerosis and loss of nephrons over a period of at least months to many years which is treated either by dialysis which includes hemodialysis [HD] and peritoneal dialysis [PD] or renal transplantation. To document the elevation of lnterleukin-6 [IL-6] in Iraqi HD patients, and to what degree that elevation influences secretion of C-reactive protein [CRP], in addition to its association with other acute phase proteins and kidney function tests. A total of 75 individuals were included in the present study, 50 individuals were treated with HD compared to 25 healthy volunteers. The level of serum IL-6 showed a significant increase in HD patients, and this elevation lead to a high increase in the secretion of CRP as well as the differences in levels of other serum acute phase proteins; ferritin revealed an increase in its level, while alb shows a decrease in its level. Kidney function tests were detected in sera of all the studied groups, which showed ran increase in urea and Cr with a decrease in CrCI in patients group