Study of the hepatoprotective effect of Juniperus phoenicea constituents
Pakistan Journal of Pharmaceutical Sciences. 2013; 26 (5): 999-1008
em Inglês
| IMEMR
| ID: emr-138422
ABSTRACT
Different fraction obtained from the aerial parts of Juniperus phoenicea showed significant activity as hepatoprotective when investigated against carbon tetrachloride induced liver injury. The hepatoprotective activity was evaluated through the quantification of biochemical parameters and confirmed using histopathology study. Phytochemical investigation of the petroleum ether, chloroform and methanol fractions utilizing different chromatographic techniques resulted in the isolation of five known diterpenoids namely 13-epicupressic acid [1], imbricatolic acid [2], 7 alpha -hydroxysandaracopimaric acid [3], 3 beta -hydroxysandaracopimaric acid [4], isopimaric acid [5], four flavonoid derivatives cupressuflavone [6], hinokiflavone [7], hypolaetin-7-O- beta -xylopyranoside [9], [-] catechin [10], inaddition to sucrose [8]. Both physical and spectral data were used for structure determination and all isolates were evaluated for their hepatoprotective activity. Compounds 2 and 6 were effective, however; 7 was the most active. Hepatoprotective activity of 7 is comparable with the standard drug silymarin in reducing the elevated liver enzymes and restoring normal appearance of hepatocytes. Hepatoprotective effect of combination of 6, 7 and silymarin with the diterpene sugiol was also explored
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Plantas Medicinais
/
Silimarina
/
Tetracloreto de Carbono
/
Extratos Vegetais
/
Biomarcadores
/
Ratos Wistar
/
Citoproteção
/
Modelos Animais de Doenças
/
Doença Hepática Induzida por Substâncias e Drogas
Limite:
Animais
Idioma:
Inglês
Revista:
Pak. J. Pharm. Sci.
Ano de publicação:
2013
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