[Determination of toxicological indexes of carbon nanotubes and Chrysotile according to invitro cytotoxicity on Human Lung epithelium cells]
Journal of School of Public Health and Institute of Public Health Research. 2013; 10 (4): 33-44
em Persa
| IMEMR
| ID: emr-138534
ABSTRACT
In this study the cytotoxicity to human epithelial lung cells of single-walled carbon nanotubes, multi-walled carbon nanotubes and chrysotile was compared based on the following cytotoxicity indices no observable adverse effect concentration [NOAEC], inhibitory concentration 50 [IC50], and Total Lethal Concentration [TLC]. Human epithelial lung cells were exposed to different concentrations [1 to 1500 micro g/ml] of carbon nanotubes and chrysotile for 6 and 24 hours. Cytotoxicity was assessed using the MTT assay. NOAEC, IC50, and TLC idices were determined by probit analysis. The results showed statistically significant correlations [p<0.001] between cytoxicity and exposure concentration in the case of all the three compounds. The NOAEC and IC50 indices were lowest for the multi-walled carbon nanotubes, while the single-walled carbon nanotubes showed the lowest TLC index. Cytotoxicity of multi-walled carbon nanotubes at low concentrations was higher than that of single-walled carbon nanotubes and chrysotile. This would mean that exposure to this compound occurs at low concentrations. Thus, cytotoxicity of multi-walled carbon nanotubes is a cause for concern. It can be concluded, then, that, like chrysotile fibers, crabon nanotubes are also considerably toxic to human epithelial lung cells
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Asbestos Serpentinas
/
Concentração Inibidora 50
/
Células Epiteliais
/
Pulmão
Limite:
Humanos
Idioma:
Persa
Revista:
J. Sch. Public Health Inst. Public Health Res.
Ano de publicação:
2013
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