Liver cystic echinococcosis: which cysts are correlated with false negative indirect passive hemagglutination [IHA]?

ABSTRACT

It's generally agreed that calcified liver cystic Echinococcosis [CE] is associated with negative serology; the influence of other cystic features on serologie result remains unclear. The aim of this study is to determine predictive factors of negative indirect passive hemagglutination [IHA] in liver CE. 119 patients operated on for liver CE, had preoperative IHA. Correlation was studied between serological result and sex, age of patient and number [single vs multiple], size, ultrasonic type [uni-locular, multivesicular, degenerative] and intrabiliary rupture of cyst. IHA sensitivity was 74.8%. Univaried analysis showed that false negative serology was correlated with age < 10 or > 20 years [p< 0.01], single cyst [p< 0.006], cystic size < 9 cm [p< 0.03] and unilocular or degenerative cyst in comparison with multivesicular type [p< 0.01 and p< 0.03 respectively]. in liver CE, cystic predictive factors of false negative IHA are single cyst, unilocular or degenerative type and size inferior to 9 cm