Prognostic value of the immunohistochemical expression of: KI67, p53, pcna and bcl2 in the superficial tumors of the bladder

ABSTRACT

To study a serie of superficial tumors of the bladder and to assess the prognostic significance of p53, Ki67, PCNA and bc!2 in these tumors. We studied 59 bladder tumors 43 pTa and 16 pTl. All Patients had cystoscopy 3 months after the resection and tumors that did not recur had a minimum follow up of 5 years. Age more than 65 years [p = 0,001], multifocality [p=0,022] and tumoral size > 3 cm [p = 0,022] were correlated with the recurrence. The expression of p53 was correlated with the recurrence in the year following the tumoral resection [p = 0,035]. That of of Ki67 was correlated with the histological grade [p = 0,03] and stage [p=0,002]. Our results suggest to practise regular endoscopic controls during the first year following the resection of the primitive tumor if it expresses p53. The immunohistochemical expression of Ki67 being correlated with the grade, this marker could help to better classify the tumors of intermediate grade