Trail to induce psoriatic skin lesion in the skin of BALB/C mice by injection of Staphylococcus aureus exotoxin

ABSTRACT

An In Vivo attempt to induce psoriatic lesions in the skin of BALB/C mice by injection of bacterial superantigen. Staphylococcus aureus that was isolated from skin lesions of psoriatic patients was subjected to gel filtration chromatography for extraction and purification of their exoproteins. The skin of BALB/C mice was injected by 0.2 ml of the extracted purified exo toxin. The induced lesions were markedly similar to that of human psoriatic lesions, although the histopathological changes were not completely mirrored to that of human psoriatic skin lesions. There is an important role of Staph. aureus exotoxin [superantigen] in induction, triggering and maintenance of psoriatic lesions