relationship between salivary beta-2 microglobulin and uremia intensity in men with chronic renal failure

ABSTRACT

This study defines the relationship between salivary beta-2 microglobulin [beta 2-M] and intensity of uremia in male patients diagnosed with chronic renal failure [CRF]. In total of 42 males were enrolled in a case-control study. There were 21 cases of CRF and 21 control cases. We collected 10cc of saliva plus 5 cc of blood from all patients to determine beta 2-M, blood urea nitrogen [BUN] and creatinine [Cr] levels. There was a correlation between the level of serum BUN and salivary urea in controls and patients, which was statistically significant for controls [p=0.028].The correlation between serum and salivary Cr was 0.195 in controls [p=0.398] and 0.598 in patients [p=0.006], which was statistically significant in patients. The correlation between serum and saliva was 0.133 [p=0.566] in controls and 0.078 [p=0.737] in patients, which was not statistically significant. The correlation between serum BUN and beta 2-M was 0.168 [p=0.469] in the control group and 0.629 [p=0.002] in patients, which was statistically significant in patients. The correlation between serum Cr and beta 2-M was 0.110 [p=0.635] in the control group and 0.678 [p=0.001] in patients, which was statistically significant in patients. The correlation between serum BUN and salivary beta 2-M was 0.093 [p=0.0690] in controls and 0.152 [p=0.152] in patients, which was not statistically significant. The correlation between serum Cr and salivary beta 2-M was 0.072 [p=0.070] in the control group and 0.286 [p=0.209] in patients, which was not statistically significant in either group. The results of the study indicated that salivary beta 2-M cannot be used as a non-invasive indicator to detect the severity of renal failure