Efficient discrimination by MIRU-VNTRs of Mycobacterium tuberculosis clinical isolates belonging to the predominant SIT11/EAI3-IND ancestral genotypic lineage in Kerala, India
International Journal of Mycobacteriology. 2013; 2 (4): 244-247
em Inglês
| IMEMR
| ID: emr-140927
ABSTRACT
The present study evaluated the ability of MIRU-VNTRs to discriminate Mycobacterium tuberculosis [MTB] clinical isolates belonging to the SIT11/EAI3-IND ancestral genotypic lineage, which is highly prevalent in Kerala, India. Starting from 168 MTB clinical isolates, spoligotyping [discriminatory index of 0.9113] differentiated the strains into 68 distinct patterns, the biggest cluster being SIT11/48 SIT11 [n = 48]. The present study shows that 12-loci MIRUs and 3 ETRs allowed an efficient discrimination of these isolates [discriminatory indexes of 0.7819 and 0.5523, respectively]
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Polimorfismo de Fragmento de Restrição
/
Repetições Minissatélites
/
Linhagem da Célula
/
Sequências Repetitivas Dispersas
/
Genótipo
Limite:
Humanos
Idioma:
Inglês
Revista:
Int. J. Mycobacteriology
Ano de publicação:
2013
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