Synthesis and antimycobacterial activity of symmetric thiocarbohydrazone derivatives against Mycobacterium bovis BCG
IJPR-Iranian Journal of Pharmaceutical Research. 2013; 12 (2): 331-346
em Inglês
| IMEMR
| ID: emr-142654
ABSTRACT
In this work, we reported the synthesis and evaluation of antimycobacterial and antifungal activity of a series of thiocarbohydrazone derivatives which are thiacetazone congeners. The target compounds were synthesized in superior yields by reacting thiocarbohydrazide with different aromatic aldehydes and methyl ketones. Compounds 8, 19 and 25 were found to be the most potent derivatives, exhibiting acceptable activity against Mycobacterium bovis BCG compared to thiacetazone and ethambutol as reference substances. Compounds 8, 15 and 25 exhibited the highest activity against Candida albicans. The most active compounds had a completely different aromatic ring system with various electronic, steric and lipophilic natures. This is understandable in light of the fact that carbohydrazone derivatives must undergo a metabolic activation step before exerting their anti-TB activity and different SAR rules govern each one of these two processes
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Estudos de Avaliação como Assunto
/
Hidrazonas
/
Antibacterianos
/
Mycobacterium tuberculosis
/
Antituberculosos
Tipo de estudo:
Estudos de avaliação
Idioma:
Inglês
Revista:
Iran. J. Pharm. Res.
Ano de publicação:
2013
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