Expression of T-cell immunoglobulin- and mucin-domain-containing molecule-3 on lymphocytes from Henoch-Schoenlein purpura patients
Iranian Journal of Pediatrics. 2013; 23 (3): 345-348
em Inglês
| IMEMR
| ID: emr-143203
ABSTRACT
To investigate T-cell immunoglobulin domain and mucin domain-containing molecule-3 [Tim-3] and its ligand galectin-9 mRNA expression in peripheral blood mononuclear cells [PBMCs] from Henoch-Schoenlein Purpura [HSP] patients. Quantitative real-time reverse transcription-polymerase chain reaction [PCR] was used to examine the mRNA expression of Tim-3 and its ligand galectin-9 in PBMCs from HSP patients. ELISA methods were used to examine the levels of serum IFN-gamma and immunoglobulin A1 [IgA1]. The Spearman rank test was used for correlation analysis between Tim-3, galectin-9 mRNA expression and serum IFN-gamma and IgA1 levels, respectively. The results showed that Tim-3 and galectin-9 mRNA expression was obviously higher in patients, which was closely correlated with serum IFN-gamma and IgA1, respectively. The results suggested that Tim-3/Tim-3L may be related to the pathogenesis of HSP
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Imunoglobulina A
/
Imunoglobulinas
/
Ensaio de Imunoadsorção Enzimática
/
Linfócitos
/
Linfócitos T
/
Interferon gama
/
Reação em Cadeia da Polimerase em Tempo Real
/
Proteínas de Membrana
Limite:
Humanos
Idioma:
Inglês
Revista:
Iran. J. Pediatr.
Ano de publicação:
2013
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