Anti-proliferation effect of Hevea brasiliensis latex B-serum on human breast epithelial cells
Pakistan Journal of Pharmaceutical Sciences. 2012; 25 (3): 645-650
em Inglês
| IMEMR
| ID: emr-144419
ABSTRACT
The rubber tree [Hevea brasiliensis] extracts are becoming increasingly visible in pharmaceutical and therapeutical research. The present study is aimed at examining the specific anti-proliferation property of H. brasiliensis latex B-serum sub-fractions against human breast cancer epithelial cell lines MCF-7 and MDA-MB231. The results showed that the latex whole B-serum and DBP sub-fraction exerted a specific anti-proliferation activity against cancer origin cells MDA-MB231 but had little effect on non-cancer-origin cells. On the other hand, the anti-proliferative activity was diminished in the pre-heated B-serum fractions. With the low toxicity that the B-serum demonstrated previously in Brine Shrimp Lethality Test [BSLT], the present results suggest the potential use of the B-serum subfractions in cancer treatment
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Artemia
/
Pão
/
Mama
/
Linhagem Celular Tumoral
/
Proliferação de Células
/
Células Epiteliais
/
Látex
Limite:
Animais
/
Feminino
/
Humanos
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Pak. J. Pharm. Sci.
Ano de publicação:
2012
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