Use of autologous fibrin glue in splenic salvage after its traumatic injuries

ABSTRACT

To avoid the well known risks of splenectomy and preserve the splenic function after its traumatic injuries, splenic salvage by using autologous fibrin glue [AFG] is particulary promising because of its unique characteristics. In this study we evaluated the efficacy and compatibility of AFG by its application to fourteen partially splenectomized New Zealand White rabbits. There was complete haemostasis in all animals, and the histopathological examination after re-exploration of the experimental animals within 24 hours, and 2 weeks revealed no body reaction and good healing. As the reparation time of AFG was suitable [30-44mins] and due to its good results on animals, we applied this material on six patients with different splenic injuries [fissures and evulsion of one pole]. Through the follow up period of two weeks by using haematocrite value, U.S., C.T, there was no recurrent bleeding from splenic sites. For that we concluded that AFG is an effective haemostatic agent with good systemic and local compatibility and can be used in splenic salvage, which therapy avoids the use of non-autologous products with their risks of diseases transmission and anaphylactic reaction