relation between HLA [Class I] and bronchial asthma

ABSTRACT

This study included forty eight patients suffering from allergic bronchial asthma in addition to 24 normal persons as a control group who were completely chest free. All individuals were subjected to full history taking, prick and intradermal skin tests for common allergens [house dust mites, mixed fungi, mixed pollens, hay dust, wool, cat hair and dog hair] and HLA [class I] typing by Micro lympnocyto-toxicity. It was found that the most prevalent allergens causing bronchial asthma were house dust mites [45.8%] and mixed fungi [20.8%]. The most common HLA [class I] associated with allergic asthma were HLA-A[1], B[8], Cw[4] and these results were statistically significant [P = < 0.01]. The asthmatic patients with house dust mites were mostly associated with HLA-A[1], B[8], Cw[6] while to mixed fungi was HLA- A[1], A[30], B[8], Cw[4]. So persons with HLA-A[1], B[8] are more susceptible to develop bronchial asthma, so we must kept him away from sources of external allergens