comparison of two regimens of intravaginal misoprostol for termination of second trimester pregnancy

ABSTRACT

The aim of the work was to compare two different regimens of intravaginal misoprostol in termination of second trimester pregnancy. In a prospective study, 60 pregnant women were admitted in the Zagazig University Hospital with the diagnosis of missed abortion of intrauterine fetal death, with gestation between 14 and 20 weeks were recruited into the study with 30 subjects in each group. Women in [group A] were given vaginal misoprostol 200 micro g every 6 h while women in [group B] were given vaginal misoprostol 400 micro g every 12h if women did not abort in 24h, the same regimen was repeated. The mean amounts of misoprostol administered in [group A] was 600 micro g [ +/- 356.22] and in [group B] was 626.67 micro g [ +/- 309.54] arid the difference was statistically insignificant. The mean induction-abortion interval in [group A] was 16.17h [ +/- 10.05] and in [group B] was 14.97h [ +/- 7.41] and the difference was statistically insignificant. After vaginal misoprostol administration, there was significantly increase in the incidence of incomplete abortion rate in [group A] than in [group B]. However there was significantly decrease in the incidences of other side effects [vomiting, diarrhoea, fever, pain] in [group A] than in [group B]. It is concluded that both regimens of vaginal misoprostol 200 micro g every 6h and 400 every 12h were effective in termination of second trimester abortion with less side effects in the first regimen