role of dyslipidaemia in pathogenesis of familial dilated cardiomyopathy and nonischemic heart failure

ABSTRACT

This study had been designed to evaluate the serum lipid profile concentrations in patients with familial dilated cardiomyopathy [FDCM] and nonischemic DCM, and search for a correlation between serum lipid concentrations and the severity of heart failure. This case controlled study was conducted in Department of Cardiology in Ibn Albitar Hospital, Baghdad and in Department of Physiological Chemistry, College of Medicine, University of Baghdad from January 2005 to November 2005. Fifty-one patients DCM were included in this study, 7 patients with FDCM [40-70 years], and the remainder 44 patients with nonischemic DCM [19-72 years old]. Twenty-five healthy subjects [21-60 years] taken as a control group. Investigations included serum estimation of total cholesterol [Tch], triglyceride [TG], low density lipoprotein-cholesterol [LDL-C], high density lipoprotein-cholesterol [HDL-C], HDL-C/LDL-C ratio and Tch/LDL-C ratio in patient and control groups. Some of the echocardiographic parameters were also measured in all patients. The mean [ +/- SD] values of serum concentrations of Tch and LDL-C did not differ significantly between patient groups and controls. Serum TG concentration was significantly increased in patients with FDCM and nonischemic DCM when compared with healthy controls [p<0.018, p<0.011; respectively]. Serum HDL-C concentration was significantly decreased in nonischemic DCM patients compared with controls [p<0.0001]. An important significant correlations were also observed between the serum lipid concentrations and the echocardiographic values in patient groups. Our data revealed that lipid profile abnormalities, in particular high serum TG and low serum HDL-C concentrations, may contribute to the development of FDCM and nonischemic DCM