Coagulopathy: influence of Schistosoma mansoni and Hbs Ag altered equilibria in post-partum preeclamptic states
EJB-Egyptian Journal of Biochemistry and Molecular Biology [The]. 1997; 15 (1-2): 211-220
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| IMEMR
| ID: emr-145577
ABSTRACT
The anticoagulants, protein C [PC], protein S [PS] and thrombin-antithrombin complex [TAT] were assessed in four selected groups involving non-pregnant cases [Group I[A]IV[A]] [G I[A]; were considered as controls, G II[A] with active schistosomiasis, G III[A] with hepatitis B surface antigen [Hbs Ag] carrier inactive state and G IV[A] with S. mansoni and Hbs Ag carrier inactive state], and allied cases immediately after delivery [Group I[B]-IV[B]]. A similar category of selected groups were assessed for those suffering from preeclampsia [PE] prior to delivery [Group I[C]-IV[C]]. The groups involved normal control group [G I], a group with schistosoma mansoni [G II], a group that were inactive Hbs Ag carrier [G III] and a group with schistosoma and inactive Hbs Ag carrier state [G IV]. Reduced PC, PS vs elevated TAT [G IV[A] > G II[A] > G III[A] > G I[A]] were presented in non-pregnant states. Assessed values immediately after delivery showed greater-magnitude of change in PE than those with normotensive pregnancies with significantly higher TAT. A relative decrease of PC and PS levels [G Iv[C] > G lic > G III[C] > G I[C]] compared to [G IV[B] > G II[B] > G III[B] > G I[B]] was apparent. Significant decrease of PC and PS were evident only in G Iv[C]. In conclusion, preeclamptic schistosomal cases with inactive Hbs Ag carrier state presented greater risk of thrombotic complications owing to inadequate complementary compensatory mechanism between PC and antithrombin III [AT III]
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Pré-Eclâmpsia
/
Esquistossomose mansoni
/
Período Pós-Parto
/
Coagulação Intravascular Disseminada
/
Antígenos de Superfície da Hepatite B
/
Hepatopatias
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Egypt. J. Biochem. Mol. Biol.
Ano de publicação:
1997
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