Treatment of unruptured ectopic pregnancy with single-dose of methotrexate

ABSTRACT

The purpose of this study was to determine success rate with single-dose intramuscular methotrexate therapy for the treatment ectopic pregnancy. This was a retrospective review of patient who were treated with methotrxate from may 2003 to April 2006. Successful treatment was defined as resolution of ectopic pregnancy without surgical intervention. Tertiary centre. Our overall success rate was 90% [90/100 patient]. The median pre treatment serum beta-human chorionic gonadotropin level was lower in those women in whom treatment was successful compared with those women with treatment failure [3158 Vs 9249mIU/ml, p<0.0001]. The median time till resolution of ectopic was 30.7 days. A positive correlation was found between pre treatment beta hCG level and time to resolution [r=0.844]. Eight patients with positive ectopic cardiac activity were treated with an 75% success rate. This large series indicates that single-dose methotrexate for treatment of ectopic pregnancy is associated with an excellent rate