Effect of different permeation enhancers on topical miconazole nitrate preparations
Journal of Drug Research of Egypt. 2009; 30 (1): 83-87
em Inglês
| IMEMR
| ID: emr-145834
ABSTRACT
Miconazole nitrate was formulated into different topical preparations, including gels with different polymers, ointments as oleaginous, water-soluble bases and cream. In vitro skin permeation studies through rabbit skin to a receptor medium of [11] Methanol phosphate buffer [pH6] For a period of 8 hour was studied. Different chemical enhancers as menthol, isopropyl myristate [IPM], oleic acid and ethanol, were incorporated into miconazole carbopol 934 P gel in different concentrations. They showed improved increase in Flux through rabbit skin. The best formula which showed significant flux was miconazole carbopol 934 p gel containing 10% menthol with the highest permeation of miconazole nitrate
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Permeabilidade
/
Administração Tópica
/
Ácido Oleico
/
Mentol
/
Miristatos
Idioma:
Inglês
Revista:
J. Drug Res. Egypt
Ano de publicação:
2009
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