Modification of the antinflammatory, antipyretic and analgesic effects of meloxicam with omeprazol or ranitidine in exeperimental animals

ABSTRACT

The potential modification of the anti-inflammatory, antipyretic and analgesic effects of meloxicam in concurrent administration of omeprazole or ranitidine was assessed. This study was divided into two sets of experiments. In the first set of experiments, male albino rats were divided into 2 main groups Group I to study the anti-inflammatory activity of the tested drugs by induction of inflammation by subcutaneous injection of 0.1mI of 20% brewer's yeast suspension into planter surface of the right hind paw and measuring the rats paw thickness according to the treatment received. Group II to study the anti-pyretic activity of the tested drugs by induction of pyrexia by subcutaneous injection of 2. 5m1 of 20% aqueous suspension of yeast dorsally and ventrally and recording the rectal temperature according to the treatment received. In the second set of experiments, mice were divided into two main groups Group I The analgesic activity of the tested drugs was evaluated by chemical method [p-benzoquinon induced-writhing response]. Group II The analgesic activity of the tested drugs was evaluated by thermal method [hot plate method]. Intraperitoneal [i.p.] administration of meloxicain produced a significant reduction in the rat paw edema [P<0. 05]. Combined i.p. injection of meloxicam and ranitidine caused a significant decrease in the rats paw edema [P<0. 05]. Also, the combined i.p injection of meloxicam and omeprazole caused a significant reduction in the rat's paw edema [P<0. 05]. Intraperitoneal administration of meloxicam into hyperthermic rats led to a remarkable reduction in body temperature of rats. Combined administration of meloxicam and ranitidine or meloxicam and omeprazole produced a significant decrease in the body temperature [P<0. 05]. The i.p administration of meloxicam before the injection of P-benzoquinon [PBQ] protected the animals against writhing response. The concurrent administration of meloxicam and ranitidine or meloxicam and omeprazole resulted in protection of animals from PBQ-induced writhing response which was significant [P<0. 05]. Furthermore, the combined administration of meloxicam and ranitidine or meloxicam and omeprazole caused a significant increase in the reaction time to thermal stimulus [P<0. 05]. On the other hand, i.p. injection of ranitidine or omeprazole alone caused non significant change in the rat's paw edema or yeast induced pyrexia, but ranitidine caused a significant decrease in PBQ-induced writhing response and in hot plate-induced pain [P<0.05]. In addition, omeprazol produced non significant change in PBQ-induced writhing response and in hot plate-induced pain. It could be suggested that in choice of the use of one of antiulcer drugs with meloxicam we prefer to use ranitidine over omeprazole as ranitidine potentiated the analgesic effect of meloxicam