Synthesis, in vitro antibacterial and antifungal activity of some n-acetylated and non-acetylated pyrazolines

ABSTRACT

Fourteen new N-acetylated and non-acetylated pyrazoline derivatives were synthesized by reacting chalcones with hydrazine in the presence of absolute ethanol however reaction was carried out in the presence of glacial acetic acid to afford N-acetylated pyrazolines. The chemical structures of the synthesized pyrazolines were confirmed by FTIR, [1]HNMR, [13]CNMR and mass spectroscopic data. The pyrazolines [1-14] were screened for antibacterial activity against ten bacterial strains using seven Gram-positive and three Gram-negative bacteria and antifungal activity against Aspergillus Flavus, Aspergillus Niger and Aspergillus pterus. Pyrazolines [1-14] found to exhibit good to excellent antimicrobial activities compared to the Levofloxacin and fluconazole used as standard drugs